Maximum Tolerated Dose (MTD) and Concentration (MTC) Effective Dose (ED) ED50 (50% of the population) ED95 (95% of the population) ADRġ1 Time Delay Causes Slow Distribution Metabolism Active Metaboliteġ2 Causes of Hysteresis Counter-clockwise Clockwise time timeĬounter-clockwise hysteresis 1) Distribution Delay (Delay to get to target to induce response)2) Response Delay (Multiple step process) 3) Active Metabolite (Needs to be converted into an active metabolite first.) 4) Sensitization (Response increases with time) Clockwise Hysteresis 1) Tolerance Potential Causes Distribution Delay Response Delay Active metabolite Sensitization Potential Causes Toleranceġ3 Cocaine and Tolerance Cocaine Other examples: Capsaicinġ8 System in Flux e.g. Response (E) Therapeutic Adverse Drug Reaction (ADR)ĥ PD Terms to Know Minimum Effective Dose (MED) and Concentration (MEC) Phoenix/WinNonlin, PK Solutions, PottersWheel, ProcessDB, SAAM II. Pharmacodynamics (PD) What the drug does to the body? Pharmacokinetics (PK) What the body does to the drug? ADMEĤ Pharmacodynamics Site of ActionResponse or Effect Pharmacokinetics sometimes abbreviated as PK, is a branch of pharmacology dedicated to. Lecture #17 Time Delays between Concentration and Response 1 MS WinNonLin Project 9/28/15: PK Modeling I project due today.Ģ Time Delays between Concentration and Response
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